The International Polycap Study 3 (TIPS-3) is a randomized double-blind placebo-controlled trial for the evaluation of Polycap (a single pill containing multiple medications), low dose aspirin and vitamin D supplementation in primary prevention of cardiovascular disease, cancer and fractures. Led by co-investigators Dr. Salim Yusuf of McMaster University and Dr. Prem Pais of St. John’s Medical College and Research Institute in Bangalore, India, the study will be conducted in 11 countries and aims to recruit over 5000 participants. The study is coordinated and sponsored by the Population Health Research Institute, McMaster University and Hamilton Health Sciences, in collaboration with research teams at each of the study sites. The Vancouver site, run through St. Paul’s Hospital, is lead by CoHeaRT’s Dr. Scott Lear and Dr. Carolyn Taylor, cardiologist at the University of British Columbia and St. Paul’s Healthy Heart Program.